@ UNIVERSITY OF NANTES
the bitterness of glucose
Dr Prieur is an associate professor at the University of Nantes and is studying the mechanism involved in adipocyte dysfunction and the associated cardiometabolic complications with a focus on diabetic cardiomyopathy
@ IHU-ICAN, AP-HP, INSERM, SORBONNE UNIVERSITY
Lipodystrophy as a
Corinne Vigouroux (MD, PhD) is Professor of Cellular Biology at Sorbonne University, and Hospital Practionner in Molecular Genetics and Endocrinology at Assistance-Publique Hôpitaux de Paris, where she coordinates the National Reference network for Rare Diseases of Insulin Sensitivity and Insulin Secretion. Her research group at Saint-Antoine Research Center (Bruno Feve’s team, Inserm U938, Paris, France) conducts translational studies focusing on molecular and cellular pathophysiology in the field of severe insulin resistance and/or lipodystrophy syndromes.
@ PASTEUR INSTITUTE, LILLE
Circadian control of metabolism & inflammation:
implications for cardiometabolic disease development
Research in Dr Helene Duez' team (Lille University) is oriented to the role of nuclear receptors in circadian biology. We study the impact of a dysregulated biological clock in the development of metabolic and cardiovascular diseases.
Associate Professor Ait-Oufella joined Pr Alain Tedgui and Pr Ziad Mallat (INSERM U689 then U970) to form a research group on cardiovascular diseases and atherosclerosis that represent the leading cause of death in developed countries. In the last decade, my group has been actively involved in the study of the cellular and molecular pathways implicated in the regulation of the immuno-inflammatory response in atherosclerosis. Current research activities address the relation between autoimmune diseases and atherosclerosis, and the role of the regulatory immune response in the prevention and/or treatment of plaque vulnerability.
@ OXFORD UNIVERSITY
in cardiometabolic disease
Dr Kerstin Timm is a British Heart Foundation Immediate Postdoctoral Basic Science Research Fellow at the Department of Physiology Anatomy and Genetics, a Stipendiary Lecturer in Medicine at Somerville College and a Lecturer in Metabolism at Corpus Christi College, University of Oxford. Her research focuses on the toxic side-effects of the chemotherapeutic agent doxorubicin on the heart. Specifically, she is using hyperpolarized MRI to study metabolic fluxes in a model of doxorubicin-induced heart failure.
CELIA MP RODRIGUES
@ LISBON UNIVERSITY
Metabolic liver disease
Full Professor at the University of Lisbon and Director of the Research Institute for Medicines (iMed.ULisboa). Her central research focus is to discover biomarkers of disease and mechanism-based molecular targets for therapeutic intervention, by focusing on signalling pathways, genetics and epigentics involved in cell death, differentiation and proliferation. She uses patient samples as well as experimental models of disease to test therapeutic strategies at preclinical level. She is past governing board member of the European Association for the Study of the Liver (EASL).
@ COCHIN INSTITUTE
Insuling signaling & glucotoxicity
Catherine Postic, PhD, is a research group leader in the Department of Endocrinology Metabolism and Diabetes at the Cochin Institute, INSERM U1016, CNRS UMR 8104 Université René Descartes in Paris. Dr. Catherine Postic has earned her doctorate at the University Paris 7 in Paris. She completed post-doctoral work at Vanderbilt University in Nashville, TN USA. Her long time interest in the control of hepatic metabolism prompted her to study the function and the regulation of the transcription factor ChREBP. Using both physiological and metabolic approaches her group made significant progress in understanding the regulation of ChREBP by glucose and assessing its function in the physiopathology of Non Alcoholic Fatty Liver Diseases (NAFLD).
@ MARSEILLE MEDICAL GENETICS,
AIX-MARSEILLE UNIVERSITY, TIMONE HOSPITAL
The role of vitamin D in cardiogenesis
2003-present INSERM (French National Institute of Health and Medical Research) Tenured Career Scientist Directeur de Recherche
1995- 2000 Visiting Scientist, Mayo Clinic,
Division Cardiovascular Diseases, Rochester, MN, USA,
May 1992-April 1993; July-October 1994 Visiting Scholar, Dept of Pharmacology, University of California at San Diego, La Jolla CA
March 2010-March 2011 Sabbatical UCSD dept Medecine- La Jolla, CA
Themes of research from Excitation-Contraction coupling, signal ttransduction in the heart to developmental biology of the heart.
@ UNIVERSITY OF EDINBURGH
Stem cell-based modelling of human
disorders of growth & insulin action
Prof Semple is based at the University of Edinburgh. His clinical and research interests centre on monogenic human disorders of growth and insulin action, encompassing insulin/PI3K/AKT signalling and primary disorders of adipose tissue function. Such rare disorders are studied in humans, cells and animals to improve understanding of pandemic “insulin resistance”, and of the mechanisms linking it to major disease, and on translating findings from the research laboratory into clinical benefits for patients.